This registration page may not work well in Internet Explorer. Please use a different browser to complete your registration.

Recorded Webinar Featuring Harry Karmouty-Quintana, Ph.D.

June 6, 2025 12:00 AM - 12:00 AM (EDT)

Description

Dr. Harry Karmouty-Quintana, Associate Professor in the Department of Biochemistry and Molecular Biology at McGovern Medical School, UT Health Houston, will present his talk entitled, "Sugar-coated scars: Hyaluronan remodeling of the lung matrix in pulmonary hypertension."

Abstract: Pulmonary hypertension (PH), a progressive vascular disease that is commonly present in chronic lung conditions such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). A hallmark of PH is vascular remodeling, yet the role of extracellular matrix dynamics in this process is not fully defined. Hyaluronan (HA), a matrix glycan elevated in IPF, COPD, and PH, is a key contributor to this remodeling. We identify pulmonary artery smooth muscle cells (PASMCs) as a central source of HA overproduction in PH, driven by 3'UTR shortening of HAS2 following loss of NUDT21, a regulator of alternative polyadenylation. This dysregulation leads to mitochondrial dysfunction and a in PASMCs, promoting proliferation, migration, and increased contractility. Mice overexpressing HAS2 in smooth muscle develop spontaneous PH, while genetic deletion or pharmacologic inhibition of HAS2 restores mitochondrial function and reverses disease features. These findings reveal a shared HA-driven mechanism linking chronic lung disease to PH pathogenesis.


Time

This recording is available 24/7 from now through 1 year anniversary of webinar.

View Event

Contact Information

North American Vascular Biology Organization
Name: Bernadette Englert
Phone: (301) 760-7745
Email: bernadette@navbo.org
We're sorry. No registrations are currently available. You may wish to contact the event organizer for assistance.
{{ vm.EventInfo.ErrorMessage }}

Select Registration Options

Edit
{{vm.regWarningMessage}}
{{vm.regAlertMessage}}

Exhibitor Opportunities

Name Price Att Qty
{{ et.Name }}
{{ et.IncludedAttendeesCount }} {{ et.AttendeeRegType.RemainingPerType }} Remaining {{ et.AttendeeRegType.RemainingPerType * -1 }} on Waiting List {{ et.AttendeeRegType.RemainingPerType * -1 }} Over Limit
{{ et.Remaining }} Remaining
 Sold out

Attendee Registration Options Total Remaining: {{ vm.EventInfo.VacantSpotsPerEvent }}

Waiting List Available
{{ vm.stats.totalAttendeesCount }} Registered , {{ vm.OverallOverAmount() }} on Waiting List , {{ vm.OverallOverAmount() }} Over Limit
Name Price Qty
{{ rt.Name }}
{{ rt.IsMemberOnly ? ' (Members Only)' : '' }}
Limit: {{ rt.LimitPerPurchase }}
Included Attendees: {{ rt.AttendeesCountPerOneRegistration }}
{{rt.Price | currency }} {{rt.PriceAfterDiscount | currency }} {{ rt.Price | currency }}
{{ rt.RemainingPerType }} Remaining
{{ rt.RemainingPerType * -1 }} on Waiting List
{{ rt.RemainingPerType * -1 }} Over Limit

{{'[[Sponsorship]] Opportunities' | localizeString:'['}}

Name Price Att Qty
{{ st.Name }}
{{ st.IncludedAttendeesCount }} {{ st.AttendeeRegType.RemainingPerType }} Remaining {{ st.AttendeeRegType.RemainingPerType * -1 }} on Waiting List {{ st.AttendeeRegType.RemainingPerType * -1 }} Over Limit
{{ st.Remaining }} Remaining
 Sold out
Continue

Registration Information

Edit

Exhibitor - {{er.Name}}

Exhibitor #{{ $index + 1 }}

Total: {{exhibitor.TotalPrice | currency}} {{ exhibitor.IsBenefit ? "- Included as a Benefit" : exhibitor.IsDiscounted ? "- Discounts have been applied" : ""}}
Exhibitor Directory
Primary Contact
Booth Information
Additional Information
Additional Items

Attendee - {{er.Name}}

{{ att.getAttendeeTerm(vm.EventSettings.AdditionalAttendeesTerm, $index) }} #{{ att.getAttendeeIndexDisplay(vm.EventSettings.AdditionalAttendeesTerm, $index) }}

Total: {{att.TotalPrice | currency}} {{att.DiscountMessage | localizeString:'['}}
A No Show fee is being assessed for {{fee.EventName}} on {{fee.EventStartLocalTimeString}}.
More Information Less information

Address

Phone

Additional Information
Event Sessions

{{slot.Name}}

{{$select.selected.SessionName}}
(full)
{{slot.SelectedSession.SessionDescription + (slot.HasFees ? " (Price: " + (slot.PriceTotal | currency) +")" : "")}}
Additional Items

{{'[[Sponsorship+]]' | localizeString:'['}} - {{er.Name}}

{{'[[Sponsor]]' | localizeString:'['}} #{{ $index + 1 }}

Total: {{sponsor.Price | currency}}
Continue

Additional Items

Edit

{{(vm.EventInfo.Terms.Donation || "Fundraising") + " Opportunities"}}

Campaign Name Item Description Amount
{{item.CampaignName}} {{item.Description + (item.ShowMinimumPrice && item.MinimumPrice ? " (Min: " + item.MinimumPrice + ")" : "")}}
Continue

Complete Registration

Edit

Terms & Conditions

No Show Policy

{{ vm.EventInfo.EventSettings.NoShowPolicy }}

Enter Promo Code

Billing Contact

Event Insurance
This event is synced to a webinar so no confirmation email will be sent from GrowthZone.

Thank you to our {{'[[Sponsor+]]' | localizeString:'['}}