This registration page may not work well in Internet Explorer. Please use a different browser to complete your registration.

Recorded Webinar: IVBM Speaker Miranda Marvel and Amber Stratman

April 7, 2023

Description

Join us as Dr. Miranda Marvel, a post doctoral researcher from the NIH,  presents "A novel epigenetic regulator of arterial specification and development in zebrafish." This lecture was featured at the 22nd International Vascular Biology Meeting.  Abstract: Epigenetic mechanisms such as DNA and histone methylation play crucial roles in gene regulation and cell differentiation during development, but most vertebrate tissue-specific epigenetic regulators are still unknown. Our lab recently developed a novel “EpiTag” transgenic epigenetic reporter zebrafish line that reliably reports tissue-specific epigenetic silencing and activation via the expression of a destabilized green fluorescent protein (GFPd2). Using this line, we performed the first ever large-scale vertebrate forward genetic screen for epigenetic-related mutants and identified a mutant in an uncharacterized histone demethylase, Kdm4ab, with defects in vascular sprouting and arterial vessel development. Transcriptomic analysis of mutants identified many dysregulated angiogenic and arterial-specific genes, with many arterial-related genes exhibiting downregulation and venous-related genes showing an unexpected upregulation in mutant tissues. Further in situ experiments revealed the upregulated venous genes are ectopically expressed in arterial vessels in kdm4ab mutants. Analysis of histone methylation in kdm4ab mutants via CUT&RUN revealed that many vascular-related genes also have aberrantly increased H3K9me3 marks, suggesting they may be targets of Kdm4ab demethylase activity during development. Our ongoing experiments are currently elucidating the endothelial cell-autonomous roles of Kdm4ab in regulating arterial differentiation and development. Our preliminary findings suggest that Kdm4ab is a novel critical epigenetic regulator of arterial specification and development, and we are further characterizing the mechanisms of action of this histone demethylase.

Time

This webinar will be available 24/7 from April 7, 2023 until April 7, 2024.

View Event

Contact Information

North American Vascular Biology Organization
Name: Bernadette Englert
Phone: (301) 760-7745
Email: bernadette@navbo.org
We're sorry. No registrations are currently available. You may wish to contact the event organizer for assistance.
{{ vm.EventInfo.ErrorMessage }}

Select Registration Options

Edit
{{vm.regWarningMessage}}
{{vm.regAlertMessage}}

Exhibitor Opportunities

Name Price Att Qty
{{ et.Name }}
{{ et.IncludedAttendeesCount }} {{ et.AttendeeRegType.RemainingPerType }} Remaining {{ et.AttendeeRegType.RemainingPerType * -1 }} on Waiting List {{ et.AttendeeRegType.RemainingPerType * -1 }} Over Limit
{{ et.Remaining }} Remaining
 Sold out

Attendee Registration Options Total Remaining: {{ vm.EventInfo.VacantSpotsPerEvent }}

Waiting List Available
{{ vm.stats.totalAttendeesCount }} Registered , {{ vm.OverallOverAmount() }} on Waiting List , {{ vm.OverallOverAmount() }} Over Limit
Name Price Qty
{{ rt.Name }}
{{ rt.IsMemberOnly ? ' (Members Only)' : '' }}
Limit: {{ rt.LimitPerPurchase }}
Included Attendees: {{ rt.AttendeesCountPerOneRegistration }}
{{rt.Price | currency }} {{rt.PriceAfterDiscount | currency }} {{ rt.Price | currency }}
{{ rt.RemainingPerType }} Remaining
{{ rt.RemainingPerType * -1 }} on Waiting List
{{ rt.RemainingPerType * -1 }} Over Limit

{{'[[Sponsorship]] Opportunities' | localizeString:'['}}

Name Price Att Qty
{{ st.Name }}
{{ st.IncludedAttendeesCount }} {{ st.AttendeeRegType.RemainingPerType }} Remaining {{ st.AttendeeRegType.RemainingPerType * -1 }} on Waiting List {{ st.AttendeeRegType.RemainingPerType * -1 }} Over Limit
{{ st.Remaining }} Remaining
 Sold out
Continue

Registration Information

Edit

Exhibitor - {{er.Name}}

Exhibitor #{{ $index + 1 }}

Total: {{exhibitor.TotalPrice | currency}} {{ exhibitor.IsBenefit ? "- Included as a Benefit" : exhibitor.IsDiscounted ? "- Discounts have been applied" : ""}}
Exhibitor Directory
Primary Contact
Booth Information
Additional Information
Additional Items

Attendee - {{er.Name}}

{{ att.getAttendeeTerm(vm.EventSettings.AdditionalAttendeesTerm, $index) }} #{{ att.getAttendeeIndexDisplay(vm.EventSettings.AdditionalAttendeesTerm, $index) }}

Total: {{att.TotalPrice | currency}} {{att.DiscountMessage | localizeString:'['}}
A No Show fee is being assessed for {{fee.EventName}} on {{fee.EventStartLocalTimeString}}.
More Information Less information

Address

Phone

Additional Information
Event Sessions

{{slot.Name}}

{{$select.selected.SessionName}}
(full)
{{slot.SelectedSession.SessionDescription + (slot.HasFees ? " (Price: " + (slot.PriceTotal | currency) +")" : "")}}
Additional Items

{{'[[Sponsorship+]]' | localizeString:'['}} - {{er.Name}}

{{'[[Sponsor]]' | localizeString:'['}} #{{ $index + 1 }}

Total: {{sponsor.Price | currency}}
Continue

Additional Items

Edit

{{(vm.EventInfo.Terms.Donation || "Fundraising") + " Opportunities"}}

Campaign Name Item Description Amount
{{item.CampaignName}} {{item.Description + (item.ShowMinimumPrice && item.MinimumPrice ? " (Min: " + item.MinimumPrice + ")" : "")}}
Continue

Complete Registration

Edit

Terms & Conditions

No Show Policy

{{ vm.EventInfo.EventSettings.NoShowPolicy }}

Enter Promo Code
This event is synced to a webinar so no confirmation email will be sent from GrowthZone.

Thank you to our {{'[[Sponsor+]]' | localizeString:'['}}