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Journal Club - January 2026

January 22, 2026 1:00 PM - 2:00 PM (EST)

Description

Edward Guzman, Ph.D., Postdoctoral Fellow at Stanford University, will present his paper entitled "Activation of the coagulation cascade as a mechanism for selective nanoparticle-mediated RNA delivery to the endothelium in vivo,” published in Science Advances. Here is a link to the paper being discussed: https://www.science.org/doi/10.1126/sciadv.ady2738

Abstract: In this manuscript, we describe the mechanism by which cationic lipid nanoparticles (LNPs) deliver RNA to the endothelium in-vivo. We demonstrate that these nanoparticles recruit coagulating proteins upon entering the bloodstream and activate the coagulation cascade -- a mechanism that promotes their uptake by endothelial cells. Our findings further reveal that generic LNPs -- such as those typically designed for RNA delivery to hepatocytes -- can be re-directed to target the endothelium of diverse tissues in-vivo, simply by pre-incubating them with pro-coagulant proteins like collagen or thrombin. This approach provides a straightforward strategy for engineering LNPs for extra-hepatic RNA delivery.

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Journal Clubs are exclusive to NAVBO members.

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Contact Information

North American Vascular Biology Organization
Name: Bernadette Englert
Phone: (301) 760-7745
Email: bernadette@navbo.org
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