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Journal Club -Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling

May 21, 2026 1:00 PM - 2:00 PM (EDT)

Description

 Kapil Thapa, a Ph.D. Student in Cell and Molecular Biology at Tulane University in Louisiana, will present the paper: " Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling," originally published in Nature Communication.  Here is a link to the paper being discussed: 
Abstract:  Filopodia formation by tip-endothelial cell is crucial for sprouting angiogenesis and tumor growth. But, how the cytoskeletal organization takes place during filopodia formation is largely unknown. Wang group in this paper found that PDZ and LIM domain 5 (PDLIM5), which is a cytoskeletal protein, is required for filopodia formation, sprouting angiogenesis, and tumor growth. Most interestingly, Endothelial-specific deletion of Pdlim5 resulted in normalization of tumor vasculature thus improving immunotherapy and chemotherapy response. The authors suggest that these findings provide invaluable insight on developing anti-angiogenic cancer therapy.


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North American Vascular Biology Organization
Name: Bernadette Englert
Phone: (301) 760-7745
Email: bernadette@navbo.org
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