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Journal Club - May 2025

May 15, 2025 1:00 PM - 2:00 PM (EDT)

Description

Please join us for our next journal club presented by Alonso Tapia, Ph.D. Candidate from City of Hope National Medical Center. He will present the paper “Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis,” originally published in Nature Communications. Here is the link to the paper being discussed:  https://www.nature.com/articles/s41467-024-50753-8 

Abstract: The following paper, “Dysregulation of MMP2-dependent TGF-β2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis” by Singh et al., explores how type 2 diabetes (T2D) disrupts vascular repair mechanisms that are essential for plaque stability. Using multi-omics data from human carotid atherosclerotic plaques and functional studies, the authors show that patients with T2D have reduced collagen content and lower levels of transforming growth factor-beta 2 (TGF-β2), a key molecule in fibrous cap formation. The study highlights that TGF-β2 is mainly produced by contractile vascular smooth muscle cells, which signal to synthetic smooth muscle cells to promote collagen production. However, in T2D, hyperglycemia interferes with MMP2-dependent activation of TGF-β2, limiting its availability and impairing this repair process. These findings suggest that dysregulated TGF-β2 signaling contributes to plaque vulnerability in T2D and point to this pathway as a potential therapeutic target for reducing cardiovascular risk.





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North American Vascular Biology Organization
Name: Bernadette Englert
Phone: (301) 760-7745
Email: bernadette@navbo.org
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