Description

Join us for our first Journal Club of the new year featuring Brenna McAllister, Graduate Student in the Center for Vascular Biology at University of Connecticut Health. She will present the paper, "Angiogenesis is promoted by hypoxic cervical carcinoma-derived extracellular vesicles depending on the endothelial cell environment" (E. Orozco-García,V., Getova,J.C., Calderón,M.C., Harmsen, R. Narvaez-Sanchez) originally published in Vascular Pharmacology.

Abstract:  Cancer needs perfusion for its growth and metastasis. Cancer cell-derived extracellular vesicles (CA-EVs) alter the tumor microenvironment (TME), potentially promoting angiogenesis. We hypothesize that conditions in the tumor, e.g., hypoxia, and in the target cells of the TME, e.g., nutrient deprivation or extracellular matrix, can affect the angiogenic potential of CA-EVs, which would contribute to explaining the regulation of tumor vascularization and its influence on cancer growth and metastasis.